Phage DNA packaging occurs by DNA translocation into a prohead. Terminases are enzymes which initiate DNA packaging by cutting the DNA concatemer, and they are closely fitted structurally to the portal vertex of the prohead to form a ‘packasome’. Analysis among a number of phages supports an active role of the terminases in coupling ATP hydrolysis to DNA translocation through the portal. In phage T4 the small terminase subunit promotes a sequence‐specific terminase gene amplification within the chromosome. This link between (...) recombination and packaging suggests a DNA synapsis mechanism by the terminase to control packaging initiation, formally homologous to eukaryotic chromosome segregation. (shrink)

The AMA Council on Ethical and Judicial Affairs (CEJA) has written a position paper on how social medical use challenges medical professionalism. The report offers persuasive ethical and practical guidelines for nonclinical internet use, specifically for social networking.This commentary provides a framework from which to apply these guidelines, but adds that there may be important situations in which physicians are not able to act in accordance. The guidelines call for professional reporting of questionable online portrayals or behaviors, but this commentary (...) argues that this may be not only cumbersome to implement, but may violate aspects of constitutional rights. While online social networking may in many ways be a new application of old challenges, there may be other aspects that require novel approaches to medical professionalism. (shrink)

In the Teubner edition, just published, I had to reduce the apparatus criticus to the smallest possible dimensions. All conjectures that were merely probable and not fairly certain had to be excluded. Some of them that are new may find a place here. There is only one MS. of Festus′ epitome of Verrius. It is now at Naples, and is said to have been found in Illyria. Dr. E. A. Loew, the leading authority on Italian script, tells us that it (...) was written at Rome towards the end of the eleventh century. It must have been rescued from a fire; for the outer edges of all the pages are burned away, so that the greater part of the outer of the two columns on each page has been lost. The chief task for editors is to fill up by conjecture these gaps in the outer columns. Scaliger won immortal fame in this work, although many of his conjectures merely followed out a suggestion of his predecessor, Augustini. Ursini and Miiller were of service in adapting to the conditions of space the stop-gaps of Scaliger, and both of them, chiefly Miiller, added excellent conjectures of their own. The conjectural supplements, printed in italics in Müller's edition, have often, especially in German students′ dissertations, been treated as if they were actually part of the text. The Hungarian editor, Emil Thewrewk, who first provided satisfactory manuscript material for Paulus′ epitome of Festus, in order to prevent this error, took the extreme course of omitting these supplements in his edition; although many of them are made absolutely certain by the words of Paulus. I have taken a middle course between Miiller and Thewrewk and have admitted the certain and the probable supplements, leaving blanks elsewhere. The supplements are printed within angular brackets, the merely probable supplements being in italic type. (shrink)

The abbreviation-symbols of the Romans, found in ancient uncial MSS., may be roughly divided into three classes: Those peculiar to juristic writing, e.g. R.P. ‘res priuata’ , Q.D.R.A. ‘qua de re agitur.’ They are properly called ‘notae iuris.’ They abound in the famous Verona MS. of Gaius. A few used in histories, etc., e.g. R.P. 'respublica' , Q. ‘Quintus’ . Valerius Probus, who compiled a manual of ancient Notae, calls this class ‘notae publicae’. They appear in such MSS. as the (...) codex Puteanus of Livy ; and since they have been transferred into modern editions of the Latin historians, etc., no one is at a loss to interpret them nowadays, although they puzzled mediaeval scribes. Symbols of ordinary words of frequent occurrence in any type of literature, e.g. Q. ‘que.’ It is this class which is the subject of this article. (shrink)

In the 'nineties the Celtic philologist, Whitley Stokes, told us in Common-room, that he once awoke muttering an incomplete stanza: Like an ogress making progress Through the spare-ribs of a child. Could anyone complete it for him ? A former Newdigate prizeman, after reflexion, produced this: Stern endeavour will be ever By some welcome find beguiled, Like an ogress making progress Through the spare-ribs of a child.

Charisivs, in his chapter on Adverbs, cites for Hispane a line of Ennius' Annals : Hispane, non Romane memoretis loqui me. Professor Norden , the apostle of Combinations-forschung, combines this fact with another fact mentioned by Livy , the celebre per Hispaniam responsum of a Spanish town to a Roman embassy. But why does he ignore a third fact which must be brought into any combination that can be convincing—the quotation of this line of Ennius by Festus in a paragraph (...) which apparently deals with Graeco-Roman affinities ? (shrink)

The Teubner edition of Festus de Verborum Significatu had scarcely appeared when Professor Anspach announced his discovery of a MS. of Isidore's Etymologies with some Scholia taken from Festus. Last Easter, in the limited time at my disposal, I transcribed from the MS. the greater part of this Isidore Commentary and, later, received a transcript of the remainder from Abbe Liebaert some weeks before his death. Although hampered by the deficiencies of our University Library, I am unwilling to keep this (...) new evidence any longer from students of Festus. (shrink)

Mrs. Dall, in her article A Seventh-Century English Edition of Virgil , shows that Virgil glosses taken from marginalia in the same MS. of the poems often preserve something of their original coherence in the two kindred glossaries, Affatim and the Second Amplonian, in spite of all the reshuffling of these two collections. Thus a small group of Virgil items appears in Affatim on p. 491 of Goetz's apograph : Carecta, Crateras, etc. The second last of this ‘Virgil cluster’ is (...) Cada: vasa vinaria. It appears also in Ampl. II. Ca[t]da: vas vinaria, and in Ampl. I. Cada: vasa vinaria, and is apparently taken , ultimately or immediately, from a marginal annotation on Aen. 1, 195 ‘uina bonus quae deinde cadis onerarat Acestes’ for in the Virgil Glossary printed by Goetz in C.G.L. IV. 427–470 we find Cadis: vasis vinariis. (shrink)

In the Phillipps Library at Cheltenham there is a MS. of the Epitome which Professor Thewrewk was unable to use for his edition. No one who knows the difficulties which attend the study of MSS. in this Library will blame him for the omission. The Phillippsianus has the form usual in codices of the Epitome , a quarto volume with two columns to the page, and with each article occupying a separate paragraph and beginning with a fairly large initial letter. (...) It was written by Ellinger , during his previous stay at Altaich, as is shown by the subscription in capital letters which stands at the end of the whole volume, : Abbas indignus ego Ellinger peccator istam glosam scripsi dum essem in Altahensi monasterio Deo sanctoque Quirino. Rogo vos omnes in ea legentes ut oretis pro me. (shrink)

In the Glossary-codex, Vat. Lat. 1469, written in the year 908, fol. 83 has been assigned to ‘glossae collectae.’ They begin : In Passione Apostolorum. Iussit eum inaumachia cathomis consumi. Cathomis: uirgis nodosis. Hie naumachia forum signat Romanorum quod Prorostris dicitur eo quod rostra, etc.. In Sancto Sebastiano. Saturnus apocatasticus : id est dispositor et destructor fatorum. Annus tuus ex diametro susceptus est. Diametrum est, etc. ‘Glossae collectae’ from the Bible and from Jerome's prefaces come next.

Isidore Etymologiae Vol. II. Books XI-XX.

We use the format of a hypothetical case study to review issues related to pharmaceutical product approval and physician prescribing practices. In this case, a new FDA-approved drug is recommended for a patient who subsequently experiences an adverse event that may or may not be related to the prescription. This case raises a number of ethical and legal considerations physicians routinely face when deciding whether to recommend such drugs for their patients. Despite the need for ongoing observation by the regulatory (...) apparatus, physicians should be cognizant of the limitations of the drug approval system and the post-approval prescription drug surveillance system. We discuss physicians’ ethical obligations when faced with a newly approved drug, including seeking out independent sources of learning, reporting adverse effects, and notifying patients about limitations in available knowledge about therapeutic recommendations. (shrink)

The Oxford Classical Texts, or Scriptorum Classicorum Bibliotheca Oxoniensis, are renowned for their reliability and presentation. The series consists of a text without commentary but with a brief apparatus criticus at the front of each page. There are now over 100 volumes, representing the greater part of classical Greek and Latin literature. The aim of the series remains that of including the works of all the principal classical authors. Although this has been largely accomplished, new volumes are still being published (...) to fill the remaining gaps, and old editions are being revised in the light of recent research or replaced. (shrink)

The line is preserved in a passage of Consentius ‘De Barbarismis et Metaplasmis’ : sicut Lucilius ‘ore corupto’; dempsit enim unam litteram per metaplasmum, r; et Ennius ‘huic statuam,’ etc.

Everyone interested in Latin Etymology knows the last word on mehercle, that the old vocative of meus is prefixed to the old Second Declension form Herclus, Voc. -lě. Without discussing whether this explanation is wholly true or partly wrong, I wish here to disqualify two pieces of evidence. Both originate from a marginal annotation on Rufinus' translation of Eusebius' Church History in, I think, a seventh-century English MS. These marginalia were used for the Leyden Glossary and for the common source (...) of the E E and Corpus Glossaries. The compiler of Leid. transferred them unaltered to his pages; and in the section devoted to Rufinus glosses we find Mehercule: mi fortis. The other compiler often recasts them for dictionary purposes. He gave this item the form Herculus: fortis . But of course the original annotation mi fortis was a mere lucky guess, and the substitution of ‘Herculus’ for Hercules was sheer ignorance. (shrink)

Gellia, of noble lineage, swore she would marry no one lower than a peer, but ultimately flung herself away on—whom? Nupsisti, Gellia, cistifero, say the two best families of MSS.; nupsisti, Gellia, cistibero says the third.

The narrow limits of the apparatus criticus in the new Clarendon Press edition have excluded these suggestions, which may find a place here:I xxix, 4 Quaedam etiam facta sunt ex nominum deriuatione, ut a prudentia ‘prudens ’; quaedam etiam ex uocibus, ut a garrulitate ‘garrulus.’ Although garrulus is the traditional reading, the derivation elsewhere of garrulus from graculus, ‘a jackdaw,’ suggests that we may read here ut a garrulitate ‘graulus.’ For the jackdaw's name in Late Latin developed from gragulus to (...) graulus. (shrink)

Egypt has not yet given us a Greek original of Plautus, unless the paltry Hibeh fragments belong to the original of the Aulularia. If they do, then Plautus departed widely from the Greek. And that is what one would expect. Read any ‘sermo’ in Plautus and see how recklessly he abandons himself to the vagaries of his humour. Clearly no ‘icily regular’ Greek is his guide there. Still a ray of light has come from Egypt that illumines one dark spot (...) in Plautus, the end of the first Scene of the Bacchides. The two sisters retreat into the house after a line which appears in our editions in this form. (shrink)

How any editor of Plautus can become one of the slash-cut-and-carve critics I cannot understand. The fair garden-beds of Plautus are scored all over with the hoof-prints of the reckless emender. Take this line of the Poenulus for example. Hanno gets a sight of his two long-lost daughters and is surprised to find how they have grown:Haecine meae sunt filiae?Quantae e quantillis iam sunt factae!His would-be son-in-law, not a very refined youth, says with a smile:Scin quid est?Thraecae sunt: in celonem (...) sustolli solent. (shrink)

Terence was studied, though not so much as Virgil, in monastery-schools. Their magistri bestirred themselves to get aid for pupils. Some famous magister— we know not who—had written, between the lines or in the margins, interpretations of difficult words in at least the three opening plays of the MS. which he used—Andr., Ad., Eun.—if not in all. These interpretations were collected from his MS. and found their way into many monastery-libraries. Goetz has published these glossae collectae of Terence from a (...) tenth century MS. in Vol. V. of his Corpus Glossariorum Latinorum, pp. 529–539; Mr. Austin has added more from a Leyden MS. , written apparently in Belgium or Holland, c. 800–815 A.D. . Probably Dr. Theander will add a further batch from a Paris MS. (shrink)

Professor Postgate speaks of ‘the regrettable silence of the principal editors of Plautus upon the subject.’ As a minor editor, I beg to defend my colleagues by pointing out that the scansions dĭŭtíus and dyūtius are subject of a note in Dziatzko's and Hauler's editions of the Phormio of Terence and in the Plautus Report in Bursian of 1879 . Also that a reference to the index of my larger edition of the Captiui will show that the word is discussed (...) in my section on Prosody : ‘The same doubt exists regarding the scansion of diutius , the by-form of the fuller form dĭūtĭŭs .’. (shrink)

Amph. prol. 90–91. In the Amphitruo Plautus runs great risk of giving oflence by bringing Jupiter on the stage. In the prologue he conciliates the audience by saying that this Jupiter is no god but a mere actor. : 26 sqq. Etenim ille quois hue iussu uenio Iuppiter Non minu' quam uostrum quiuis formidat malum: Humana matre natus, humano patre, Mirari non est aequom sibi si praetimet.

Cicero defines gloria as frequens de aliquo fama cum laude, ‘much talk about a person to his praise.’ When the talk is by the person himself, the word takes the signification ‘boast’.

The Placidus Glossary was hailed in Ritschl's time as a new clue to Plautus' true text. And Buecheler, Ritschl's pupil, seized on its Alapari est alapas minari, etc., and foisted this verb on Plaut. True. 928. The great Latin Thesaurus quotes the line with this piece of new cloth put on an old garment: nil alapari satiust, miles, instead of the correct philippiari satiust, miles.